This course delves into the foundational theories and cutting-edge advancements in large language models (LLMs). The course emphasizes LLM's application in real-world scenarios, focusing on topics such as domain-specific LLMs (e.g., continuous pretraining, SFT, and RLHF), data-intensive and document-intensive scenarios (e.g., NL2SQL RAG). Active student participation is encouraged through mini-projects, presentations, and discussions, providing hands-on experience in leveraging LLMs for real-world challenges.