As the demand for advanced computing systems continues to grow, the need for efficient design automation and optimization techniques becomes paramount. This course delves into the cutting-edge field of design optimization for the critical areas of 2.5D/3D integrated circuits (ICs), mixed-signal circuits, and photonic circuits. The course will cover fundamental principles and cross-layer design optimization techniques to enhance the design process and paramount criteria, including PPA, thermal, signal integrity, cost, etc. Students will explore various methodologies and tools to streamline the design process for various emerging technologies.